Oxford Endovascular was spun out of Oxford University’s Engineering Science and Surgical Science Departments in December 2015 to commercialise OxiFlow™, a novel, blood Flow Diversion device (specialised ‘micro stent’) for treating Intracranial (Brain) Aneurysms (ICAs).
A weakened point in a blood vessel, aneurysms occur where pulsing blood pressure causes the vessel wall to balloon. ICAs, if untreated, can rupture causing bleeding into the brain which can lead to irreparable brain damage and death. OxiFlow™ is a tiny mesh tube or ‘Origami Engineering for the Brain’ that fits the natural shape of the blood vessel in the brain and, inserted via a microcatheter, diverts blood away from the ICA, allowing it to heal.
Professors James Byrne & Zhong You
James is a Professor of Neuroradiology at the University of Oxford, is one of the inventors of the OxiFlow device. He has decades of experience operating on aneurysm patients and was the first person to perform endovascular coiling in the UK. His experience using braided flow-diverters led to the collaboration to create OxiFlow. He has Fellowships at UCSF and UCLA in the US and held the Presidency of the European Society of Minimally Invasive Neurological Therapy.
Zhong You is Professor of Engineering at the University of Oxford, and is one of the inventors of the OxiFlow device. He is a leading expert on deployable structures that can be collapsed for delivery and subsequently deployed at the site of interest and has substantial expertise in the laser cutting required to create the OxiFlow. He has previously founded a spinout company Oxstent Medical Devices developing an endovascular stent for the treatment of aortic aneurysms.