Base4 Innovation

Base4 Innovation is a Cambridge-based company developing a new DNA sequencing technology that has the potential to disrupt a large and growing market currently dominated by Illumina.

The sequencing technology involves enzymatically cleaving sequential nucleotides from a strand of DNA and encapsulating them in water microdroplets suspended in oil. A proprietary biochemical reaction inside each droplet generates a fluorescent signal unique to the nucleotide. Base4 Innovation is currently developing a prototype benchtop sequencing device, aiming to increase access to rapid DNA sequencing by lowering the cost barriers to researchers.

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